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Index > Protein center > Lipe(Gene name) > Mouse
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  • Lipe (Gene name),
  • Hormone-sensitive lipase (Protein name ),  LIPS_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Lipe;
    Protein name:
    Hormone-sensitive lipase(HSL);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with PTRF in the adipocyte cytoplasm.
    Function:
    In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
    Subcellular Location:
    Cell membrane Membrane caveola Cytoplasm cytosol Found in the high-density caveolae (By similarity). Translocates to the cytoplasm from the caveolae upon insulin stimulation.
    Protein Attributes:
    Sequence length:
    759
    Sequence:
    50:
    MDLRTMTQSL | VTLAEDNMAF | FSSQGPGETA | RRLSNVFAGV | REQALGLEPT | 
    100:
    LGQLLGVAHH | FDLDTETPAN | GYRSLVHTAR | CCLAHLLHKS | RYVASNRKSI | 
    150:
    FFRASHNLAE | LEAYLAALTQ | LRAMAYYAQR | LLTINRPGVL | FFEGDEGLTA | 
    200:
    DFLQEYVTLH | KGCFYGRCLG | FQFTPAIRPF | LQTLSIGLVS | FGEHYKRNET | 
    250:
    GLSVTASSLF | TGGRFAIDPE | LRGAEFERII | QNLDVHFWKA | FWNITEIEVL | 
    300:
    SSLANMASTT | VRVSRLLSLP | PEAFEMPLTS | DPRLTVTISP | PLAHTGPAPV | 
    350:
    LARLISYDLR | EGQDSKVLNS | LAKSEGPRLE | LRPRPHQAPR | SRALVVHIHG | 
    400:
    GGFVAQTSKS | HEPYLKNWAQ | ELGVPIFSID | YSLAPEAPFP | RALEECFFAY | 
    450:
    CWAVKHCDLL | GSTGERICLA | GDSAGGNLCI | TVSLRAAAYG | VRVPDGIMAA | 
    500:
    YPVTTLQSSA | SPSRLLSLMD | PLLPLSVLSK | CVSAYSGTEA | EDHFDSDQKA | 
    550:
    LGVMGLVQRD | TSLFLRDLRL | GASSWLNSFL | ELSGRKPQKT | TSPTAESVRP | 
    600:
    TESMRRSVSE | AALAQPEGLL | GTDTLKKLTI | KDLSNSEPSD | SPEMSQSMET | 
    650:
    LGPSTPSDVN | FFLRPGNSQE | EAEAKDEVRP | MDGVPRVRAA | FPEGFHPRRS | 
    700:
    SQGVLHMPLY | TSPIVKNPFM | SPLLAPDSML | KTLPPVHLVA | CALDPMLDDS | 
    750:
    VMFARRLRDL | GQPVTLKVVE | DLPHGFLSLA | ALCRETRQAT | EFCVQRIRLI | 
    759:
    LTPPAAPLN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse HSL
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    E1276m
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    ELISA Kit for Mouse HSL
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    E1276r
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    ELISA Kit for Mouse HSL
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    ELISA Kit for Mouse HSL
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    E1276h
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    ELISA Kit for Mouse HSL
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    E1276p
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    CLIA Kit for Mouse HSL
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    U1276p
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    96T
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    CLIA Kit for Mouse HSL
    Cat.:
    U1276r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse HSL
    Cat.:
    U1276h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse HSL
    Cat.:
    U1276m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse HSL
    Cat.:
    U1276b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse HSL
    Polyclonal Antibody for Mouse HSL
    Polyclonal Antibody for Mouse HSL
    Cat.:
    P1276Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse HSL
    Cat.:
    P1276Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse HSL
    Cat.:
    P1276Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse HSL
    Monoclonal Antibody for Mouse HSL
    Monoclonal Antibody for Mouse HSL
    Monoclonal Antibody for Mouse HSL
    Monoclonal Antibody for Mouse HSL
    Protein for Mouse HSL
    Protein for Mouse HSL
    Protein for Mouse HSL
    Protein for Mouse HSL
    Protein for Mouse HSL

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    Precision
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of the gene for mouse hormone-sensitive lipase."
      Li Z. , Sumida M. , Birchbauer A. , Schotz M.C. , Reue K.
      Genomics24:259-265(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Hormone-sensitive lipase (Lipe): sequence analysis of the 129Sv mouse Lipe gene."
      Sztrolovics R. , Wang S.P. , Lapierre P. , Chen H.S. , Robert M.-F. , Mitchell G.A.
      Mamm. Genome8:86-89(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129/Sv.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Testis.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFOM 1)
      strain: FVB/N.
      tissue: Salivary gland.
    6. 6.
      "Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes."
      Daval M. , Diot-Dupuy F. , Bazin R. , Hainault I. , Viollet B. , Vaulont S. , Hajduch E. , Ferre P. , Foufelle F.
      J. Biol. Chem.280:25250-25257(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY AMPK
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    8. 8.
      "Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins."
      Wang H. , Hu L. , Dalen K. , Dorward H. , Marcinkiewicz A. , Russell D. , Gong D. , Londos C. , Yamaguchi T. , Holm C. , Rizzo M.A. , Brasaemle D. , Sztalryd C.
      J. Biol. Chem.284:32116-32125(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLIN5
    9. 9.
      "The stoichiometry of protein phosphorylation in adipocyte lipid droplets: analysis by N-terminal isotope tagging and enzymatic dephosphorylation."
      Kanshin E. , Wang S. , Ashmarina L. , Fedjaev M. , Nifant'ev I. , Mitchell G.A. , Pshezhetsky A.V.
      Proteomics9:5067-5077(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-559
    10. 10.
      "Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance."
      Liew C.W. , Boucher J. , Cheong J.K. , Vernochet C. , Koh H.J. , Mallol C. , Townsend K. , Langin D. , Kawamori D. , Hu J. , Tseng Y.H. , Hellerstein M.K. , Farmer S.R. , Goodyear L. , Doria A. , Blueher M. , Hsu S.I. , Kulkarni R.N.
      Nat. Med.19:217-226(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS LIPOLYTIC ENZYME
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